Effect of albumin on phenytoin concentration: are we flogging a dead horse?
نویسندگان
چکیده
C JHP – Vol. 64, No. 4 – July–August 2011 JCPH – Vol. 64, n 4 – juillet–août 2011 References 1. Dubrey SW, Banner N. Home inotrope treatment for intractable heart failure following heart transplantation. Heart 1999;82(2):248-251. 2. Jiménez J, Jara J, Bednar B, Bauerlein J, Mallon S. Long-term (> 8 weeks) home inotropic therapy as destination therapy in patients with advanced heart failure or as bridge to heart transplantation. Int J Cardiol 2005;99(1):47-50.
منابع مشابه
Clinical decision support of therapeutic drug monitoring of phenytoin: measured versus adjusted phenytoin plasma concentrations
BACKGROUND Therapeutic drug monitoring of phenytoin by measurement of plasma concentrations is often employed to optimize clinical efficacy while avoiding adverse effects. This is most commonly accomplished by measurement of total phenytoin plasma concentrations. However, total phenytoin levels can be misleading in patients with factors such as low plasma albumin that alter the free (unbound) c...
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The cytochrome P450 (P450)-dependent conversion of phenytoin (PHT) to p-hydroxy phenytoin (pHPPH), and tolbutamide (TLB) to 4-hydroxy tolbutamide (hydroxy-TLB), in human liver microsomes was studied in the presence of increasing concentrations (0-4%) of bovine serum albumin (BSA). Therefore, the free fraction (f(u)) of PHT and TLB varied. Whereas the f(u) of PHT (5 microM) decreased, an increas...
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This study characterized the mechanism by which bovine serum albumin (BSA) reduces the K(m) for phenytoin (PHY) hydroxylation and the implications of the "albumin effect" for in vitro-in vivo extrapolation of kinetic data for CYP2C9 substrates. BSA and essentially fatty acid-free human serum albumin (HSA-FAF) reduced the K(m) values for PHY hydroxylation (based on unbound substrate concentratio...
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عنوان ژورنال:
- The Canadian journal of hospital pharmacy
دوره 64 4 شماره
صفحات -
تاریخ انتشار 2011